Unexpected immunoregulation effects of D-lactate, different from L-lactate

With advances in the study of human microbiome, fact that lactate is smallest chiral molecule nature has drawn attention. However, there have been few comparative studies on classification L-lactate and D-lactate. In this study, we investigated safety efficacy D-lactate as an immunomodulator food origin. terms evaluation, both lactates were found to promote cell proliferation repair. was well tolerated for 30 d at doses up 2000 mg/kg mice. immune function unexpectedly, enhance immunity by increasing organ index, ear swelling lymphocyte conversion rate, haemolysis rate macrophage phagocytosis had a dose-dependent effect. showed stronger regulation effects than L-lactate. This proves immunoregulation capacity provides mechanistic basis bioactivity fermented foods.